When Chelsea Handler tried to fat-shame Andy Richter on Conan, Richter had a clever response that only he could pull off.
"Do you float a lot in the ocean?" Handler asked Richter.
"Sure. What, do you sink?" Richter replied. "Might be that cast-iron heart."
Richter's joke came after Handler told her story about the one time actor Jason Biggs peed on her face.
Celebrity gossip mag Us Weekly spoke about Conan's decision to bring up the subject in the first place:
"There's this horrifying video on the web," O'Brien noted of actress Jenny Mollen's viral Vine from last month involving the American Pie actor and comedienne. "Jason Biggs is standing on what appears to be a dock, and there's no other way to say it…. He's urinating on you. I had to bring it up because I think we need an explanation."
Lesson of the day? Dirty humor will sometimes lead to fat-jokes.